Research

Member information on Current Research Projects being undertaken by our Members

1.

 Title: Outcomes of nodal metastatic cutaneous squamous cell carcinoma of the head and neck treated in a regional centre

 Chief Investigators:

Author name

Degrees/
Fellowships

Position

Institution

Campbell Schmidt*

MBBS

Student

University of Queensland

Jarad Martin

MBChB, FRANZCR

Co-supervisor

Calvary Mater Newcastle

Eric Khoo

MBChB, FRANZCR

Co-supervisor

Radiation Oncology Queensland

Ashley Plank

PhD

Statistician

Radiation Oncology Queensland

Roger Grigg

MBBS, FRACS

Supervisor

University of Queensland

Contact Person (ie. Dept Secretary etc.: Dr Roger Grigg

Information provided by ANZHNCS Member: Dr Roger Grigg

 _____________________________________________________________________________________

2.

Title: The Use of Fine Needle Aspiration Cytology in the Diagnosis of Neoplastic and Non-neoplastic Parotid Masses - a Single Centre Study

Chief Investigator:

Courtenay Henrys, Year 3 MBBS. BAppSci (Human Movement Studies)

Research Supervisor,  Dr Roger Grigg MBBS FRACS

Contact Person (ie. Dept Secretary etc.: Dr Roger Grigg

Information provided by ANZHNCS Member:  Dr Roger Grigg

_____________________________________________________________________________________

3.

Title: HPV rates in normal tonsils

Chief Investigator

Research Supervisor,  Dr Roger Grigg MBBS FRACS

Contact Person (ie. Dept Secretary etc.: Dr Roger Grigg

Information provided by ANZHNCS Member:  Dr Roger Grigg

_____________________________________________________________________________________

4.

Title: Dietetic research project looking at prophylactic oral nutritional supplementation for patients undergoing radical intent radiotherapy to the head and neck region.

Chief Investigator: Sarah Deacon, Townsville Hospital

Contact Person (ie. Dept Secretary etc.:  Sarah Deacon, Townsville Hospital
Email:  Sarah.Deacon@health.qld.gov.au

Information provided by ANZHNCS Member:  Sarah Deacon

_____________________________________________________________________________________

5.

Titles:

  1. N. Beech, M. Batstone, S. Porceddu – the impact of preradiotherapy dental extractions on the development of osteoradionecrosis and quality of life

  2. M. Batstone, O. Ellis – Frozen sections and their influence on surgical margins in oral cavity cancer

  3. Gore S, Clark J, Batstone M, Crombie A – chemoradiotherapyvs surgery and adjuvant xrt for the management of oral cavity cancer

  4. M. Batstone – comparative analysis of jejunal free flap and tubed fasciocutaneous flaps for pharyngolaryngectomy defects

  5. Farah C, Batstone M + others – narrow band imaging and molecular margin analysis in head and neck

  6. Batstone M, Subramaniam S, Sharp D – the cost effectiveness of free flap monitoring

Chief Investigators

  1. Nick Beech nicholasbeech@gmail.com

  2. Martin Batstone martin.batstone@health.qld.gov.au

  3. Jonathon Clarke jcjc@tpg.co

  4. Martin BAtstone martin.batstone@health.qld.gov.au

  5. Camile Farah c.farah@uq.edu.au

  6. Shiva Subramaniam shivasubramaniam@gmail.com

Contact Person (ie. Dept Secretary etc.:
Ms Pauline Haley (07) 3646 7681
Email: pauline.haley@health.qld.gov.au

Information provided by ANZHNCS Member:  Dr Martin Batstone

_____________________________________________________________________________________

6.

Titles:

  1. 1.HPV in oropharynx

  2. Epidemiology of H&N Cancers

  3. Identification of molecular and immuno diagnostic cancer markers in Northern Territory population


Chief Investigator:

Dr Mahiban Thomas

Contact Person (ie. Dept Secretary etc.: Dr Mahiban Thomas

Information provided by ANZHNCS Member:  Dr Mahiban Thomas, Darwin Hospital

_____________________________________________________________________________________

7.

Title:  TROG POST study

Chief Investigator:
Dr Iain Ward

Contact Person (ie. Dept Secretary etc.: Dr Iain Ward

Information provided by ANZHNCS Member:  Dr Iain Ward, The Canterbury Regional Cancer and Haematology Service

 _____________________________________________________________________________________

8.

Titles:

  1. Sample Saliva Test to Diagnose Head and Neck Cancer at an Early Stage –  with Chamindie Punyadeera  

  2. Defining the role of HPV in causation of Oral Cavity Cancers in Non-Smokers

Chief Investigator:

Dr Chris Perry

Contact Person (ie. Dept Secretary etc.:  Dr Chris Perry

Information provided by ANZHNCS Member:  Dr Chris Perry, Brisbane ENT 

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9.

Titles: 

a)  Further studies regarding biomarkers for non- smoking, non-drinking patients who develop oral squamous cell carcinomas. PhD project

S. Belobrov,  D. Wiesenfeld, M. McCullough, 

b)  Oral yeasts’ carriage and biofilm forming ability and exfoliative cytology in oral cancer patients. PhD project

A. Al Nuami, D. Wiesenfeld, M.McCullough

c) Molecular Oncogenesis of Oral Cavity and Oropharyngeal Squamous Cell Carcinoma PhD Project

K Koo,T Iseli, D Wiesenfeld, A Burgess

d) A role for panendoscopy? Second primary tumours in early stage squamous cell carcinoma of the oral tongue

           K Koo, R Harris, D Wiesenfeld, T Iseli

Chief Investigators:

Dr Tim Iseli, Michael McCullough

Contact Person (ie. Dept Secretary etc.:  Dr Tim Iseli, Michael McCullough

Information provided by ANZHNCS Member:  Dr Tim Iseli, Michael McCullough, Dr David Wiesenfeld, Royal Melbourne Hospital 

____________________________________________________________________________________

10.

Title: "The incidence of Osteoradionecrosis over a 3 year period in Head & Neck SCC patients"

Supervisor: Dr. Richard Lewis Email: drlewis@ohns.com.au 

Chief Investigator: Dr. Jae Park  Email: parja731@yahoo.com

Contact Person (ie. Dept Secretary etc.: Dr. Jae Park; Dr. Richard Lewis

Information provided by ANZHNCS Member:  Dr Richard Lewis, Perth WA

___________________________________________________________________________________

11.

Queensland Head and Neck Cancer Centre

Translational Research Activities

Cancer Biology

  • 1. Individualising care in head and neck cancer using genetic markers of cancer progression to guide drug target selection in a mouse model
  • 2. Tissue microarray analysis of oropharyngeal SCC tumour specimens
  • 3. Defining the role of HPV in the causation of oral cavity cancers in non-smokers / Viral oncogenesis in oral squamous cell carcinoma.
  • 4. Studying the factors involved in the perineural spread of cutaneous squamous cell carcinomas of the head and neck
  • 5. Perineural spread of cutaneous malignancy in a live mouse model and ganglion tumour coculture model
  • 6. Optimising intratumoural treatment of HNSCC mouse models with a novel drug EBC-46
  • 7. The role of LoxL2 in perineural invasion of cutaneous squamous cell carcinoma
  • 8. Studies on squamous carcinoma formation and the development of novel therapies

 Rhinosinusitis

  • 9. High throughput screening of bioactive extracts for anti-inflammatory properties and the development of an in-situ nasal gelling drug delivery system for the treatment of chronic rhinosinusitis

 Imaging

  • 10.Evaluation of accuracy of 3T MRI in evaluation of head and neck perineural invasion

 Epidemiology

  • 11. Head and Neck Cancer Study

 Clinical Trials

  • 12. Phase I dose-escalation study to determine the safety and tolerability of an intratumoural injection of EBC-46 in patients with refractory cutaneous or subcutaneous tumours
  • 13. A pilot study of an old drug with a new use – prochlorperazine to improve anti-EGFR therapy in squamous cell carcinoma of the mucosa
  • 14. Phase I/II open-label clinical trial of autologous EBV-specific T cell therapy as consolidative treatment following chemotherapy for metastatic EBV-associated NPC

Surgical Trial

  • 15. Primary trans-oral surgical management of early tonsillar squamous cell carcinoma followed by risk-adapted radiotherapy
  • 16. Drop Neck Study Assessment of need for neck dissection in cutaneous metastatic disease to the parotid:

 Diagnostics

  • 17. A simple saliva test to diagnose head and neck cancer at an early stage
  • 18. A saliva-based method for the detection of HPV-associated oral cancers
  • 19. Salivary glycoproteins as biomarkers for head and neck squamous cell carcinoma
  • 20. To develop a method to detect circulating tumour cells (CTC's) in metastatic head and neck squamous cell carcinoma
  • 21. Identification of breath biomarkers from head and neck SCC

Information provided by Andrew Wetzig, Research Coordinator, Queensland Head and Neck Cancer Centre; ANZHNCS Member A/Prof Ben Panizza, PA Hospital, Brisbane, Qld